Protective effect of nobiletin against apoptosis induced by 6-hydroxydoamine in human neuroblastoma cells
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منابع مشابه
Involvement of Mu Opioid Receptor Signaling in The Protective Effect of Opioid against 6-Hydroxydopamine-Induced SH-SY5Y Human Neuroblastoma Cells Apoptosis
Introduction: The neuroprotective role of opioid morphine against 6-hydroxydopamineinduced cell death has been demonstrated. However, the exact mechanism(s) underlying such neuroprotection, especially the role of subtype receptors, has not yet been fully clarified. Methods: Here, we investigated the effects of different opioid agonists on 6-OHDA-induced neurotoxicity in human neuroblastoma...
متن کاملinvolvement of mu opioid receptor signaling in the protective effect of opioid against 6-hydroxydopamine-induced sh-sy5y human neuroblastoma cells apoptosis
introduction: the neuroprotective role of opioid morphine against 6-hydroxydopamineinduced cell death has been demonstrated. however, the exact mechanism(s) underlying such neuroprotection, especially the role of subtype receptors, has not yet been fully clarified. methods: here, we investigated the effects of different opioid agonists on 6-ohda-induced neurotoxicity in human neuroblastoma sh-s...
متن کاملProtective Effect of Folic Acid against Apoptosis Induced by Ischemia/Reperfusion Injury in Rat Liver
The anti-apoptotic gene bcl-2 is located in mitochondria, but it is uncertain whether its expression affects hepatocyte survival in ischemia/reperfusion (I/R) injury. This experiment was designed to evaluate the role of folic acid in expression of bcl-2 in I/R in rat liver. Eighteen Wister rats were divided into sham-operated controlgroup (C) (n=6), I/R group (...
متن کاملP 36: Protective Effects of Crocin on D-Galactose Induced Aging Model in Human Neuroblastoma Cells
Introduction: D-galactose (D-gal) is well known as an appropriate agent to induced aging effects in the in vivo and in vitro models. In the present study, we selected crocin, the main constituent of Crocus sativus L. (Saffron), against D-gal cytotoxicity in human neuroblastoma SH-SY5Y cells. Materials and Methods: Cells were pretreated with crocin (25-500 µM) for 24 h and then expos...
متن کاملParkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis.
Parkinson's disease (PD) is characterized by the selective degeneration of dopaminergic (DA) neurons in substantia nigra pars compacta (SNpc). A combination of genetic and environmental factors contributes to such a specific loss. Among the five PD-linked genes identified so far, parkin, a protein-ubiquitin E3 ligase, appears to be the most prevalent genetic factor in PD. Although a variety of ...
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ژورنال
عنوان ژورنال: Physiology and Pharmacology
سال: 2019
ISSN: 2476-5236,2476-5244
DOI: 10.32598/ppj.24.1.20